POS-007 MAGNITUDE AND ASSOCIATED RISK FACTORS OF NEONATAL ACUTE KIDNEY INJURY IN THE NEONATAL INTENSIVE CARE UNIT OF TIKUR ANBESSA SPECIALIZED HOSPITAL, ADDIS ABABA, ETHOPIA

Acute kidney injury (AKI) is an important clinical problem among sick neonates. The main etiologies of AKI include sepsis, hypovolemia, asphyxia, nephrotoxic drugs and urinary tract congenital anomalies. diagnosis in neonates made when urine output <1ml/kg/hr. or anuria for the first 48 hours serum Creatinine level ≥1.5mg/dl increase by 0.2 to 0.3mg/dl within hours. exact prevalence not well known but according various studies globally it estimated be between 11 56%. Hence, aim present study assess incidence risk factors associated with neonatal AKI. A prospective observational cross sectional was done admitted NICU TASH from May July 2020.The data were entered analyzed using SPSS version 25.Data cleaning screening conducted exclusively principal investigator. Descriptive statistics employed summarize presented Tables Figures. Binary logistic regression analysis asses predicting .p-value <0.05 considered as statistically significant. total 245 who fulfilled inclusion criteria enrolled. Most patients (41.6%) range 1-7 days life. Male accounted 55.5% cases. majorities (70.7%) term 11.8% them preterm. One hundred forty four (58.8%) delivered outside most (57.6%) via spontaneous vertex delivery. More than half patient took during admission those 47.8% ampicillin plus gentamicin only 58% started breast feeding one hour based on KDIGO 12.7 %( n=31). After adjusting potential co-founders maternal age group (AOR=0.1, 95%CI: 0.1, 0.7), perinatal asphyxia (AOR=13.1, 1.1, 166.1) treatment dehydration (AOR=8.7, 1.6, 48.2) significantly increased developing However higher mortality 41.9 % revealed this study. Nine (29%) discharged abnormal Creatinine. uncommon our ICU mortality. It therefore identify high monitor function thoroughly.